Journal: Materials Today Bio

Article Title: Systemic Immunity Triggered by Boron Neutron Capture Therapy via Manganese-Borate Complex

doi: 10.1016/j.mtbio.2026.102904

Figure Lengend Snippet: Assembly and hydrogen peroxide-responsive release of Albumin@MnB. a, Self-assembly after coordination with different metal ions with B and 4B. b , The structural formula for B and 4B. c , Scheme of coordination self-assembly of Mn 2+ and albumin. d , Schematic illustration of the assembly principle between albumin and 4B. e , Particle size analysis of Albumin@MnB and MnB. f , Zeta potential analysis of Albumin@MnB and MnB. g , Transmission electron microscopy (TEM) image of Albumin@MnB. h , Elemental distribution in this protein formulation (Scale bars, 200 nm). i , Disassembly of different metal ions coordinated with 4B in response to H 2 O 2 . j , Particle size analysis of Albumin@MnB under H 2 O and H 2 O 2 conditions. k , TEM images of Albumin@MnB under H 2 O and H 2 O 2 conditions (Scale bars, 200 nm). l-m , Release of boron and Mn from the protein formulation at different H 2 O 2 concentrations (n=3, Data represent mean ± s.d.). o , Laser Scanning Confocal Microscopy (LSCM) images of 4T1 and 3T3 cells (Scale bars, 100 μm). p , Schematic illustration of the disassembly principle of the protein formulation under H 2 O 2 conditions.

Article Snippet: The transmission electron microscopy (TEM) images were taken on a JEOL JEM-2200FS microscope.

Techniques: Particle Size Analysis, Zeta Potential Analyzer, Transmission Assay, Electron Microscopy, Formulation, Confocal Microscopy

Journal: bioRxiv

Article Title: Weckle is a molecular switch that diverts Toll signalling from innate immunity towards growth by engaging Yki

doi: 10.64898/2026.02.18.706625

Figure Lengend Snippet: (A) Diagram of Glycine2 and Serines in Wek tested. (B) Mass spectrometry of purified Wek-FLAG: S2 cells were co-transfected with wek-FLAG and Toll-6HA, or wek-FLAG and pelle-HA and stimulated with purified DNT-2, Wek was purified, and found to be phosphorylated at Ser164. This Ser was not phosphorylated in controls. (C,D) Phostag gel of wek mutant forms expressed in S2 cells, showing: (C) western blot input; (D) Phostag gel, showing the distinct migration profile of the Wek mutant forms. Asterisks indicate bands modified by the co-transfection with Pelle. (E,F) Microscopy from transfected S2 cells showing that site directed mutagenesis of wek in G2A, S164A and S168A, alter the subcellular distribution of Wek, and this is further influenced by pelle . Wek visualised with anti-FLAG antibodies (green) and nuclei with DAPI (magenta). (G) Illustration showing that phosphorylation at Ser6 and Ser168 are required for the nuclear translocation of Wek. Scale bar: (E,F) 10μm

Article Snippet: To analyse glial cell membrane volume in adult antennal lobes, laser scanning confocal microscopy image data were processed with Imaris using the “Surface” module.

Techniques: Mass Spectrometry, Purification, Transfection, Mutagenesis, Western Blot, Migration, Modification, Cotransfection, Microscopy, Phospho-proteomics, Translocation Assay